Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 14/20 | 0.73 |
| ▸ | MET | P08581 | 6/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.62 |
| ▸ | MERTK | Q12866 | 4/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | HCK | P08631 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895371 | 0.91 | AXL (0.74) | AXLMETKDRPDGFRAMERTK | |
| SCHEMBL1897070 | 0.89 | AXL (0.82) | AXLMETKDRPDGFRAMERTK | |
| Zanzalintinib SCHEMBL29378531 | 0.84 | AXL (1.00) | AXLMETKDRMERTKAURKA | |
| Zanzalintinib SCHEMBL21200856 | 0.84 | AXL (1.00) | AXLMETKDRMERTKAURKA | |
| SCHEMBL24906742 | 0.84 | AXL (0.77) | AXLMETKDRPDGFRAMERTK | |
| SCHEMBL4771206 | 0.84 | AXL (0.74) | AXLMETKDRPDGFRAMERTK | |
| SCHEMBL5204152 | 0.84 | PDGFRA (0.75) | AXLKDRPDGFRAKITFLT3 | |
| SCHEMBL21200566 | 0.83 | AXL (0.84) | AXLMETKDRMERTKAURKA | |
| SCHEMBL1894371 | 0.83 | AXL (0.63) | AXLMETKDRPDGFRAMERTK | |
| SCHEMBL21201281 | 0.82 | AXL (1.00) | AXLMETKDRMERTKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |