Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208016 | 0.87 | ABL1 (0.43) | KDRPDGFRBHDAC1HDAC2TNKS2 | |
| SCHEMBL3212557 | 0.87 | TNKS (0.49) | KDRPDGFRBHDAC1HDAC2HDAC8 | |
| SCHEMBL3204800 | 0.86 | KDM4E (0.43) | KDRPDGFRBHDAC8HDAC6BTK | |
| SCHEMBL3212756 | 0.85 | CDC7 (0.42) | KDRPDGFRBALOX5APFEN1 | |
| SCHEMBL3206124 | 0.85 | FEN1 (0.44) | BRD4KDRPDGFRBHDAC6TNKS2 | |
| SCHEMBL3194644 | 0.84 | TNKS2 (0.53) | HDAC1HDAC2HDAC8HDAC6TNKS2 | |
| SCHEMBL3834383 | 0.84 | ABL1 (0.36) | KDRPDGFRBTNKS2TNKSIDO1 | |
| SCHEMBL9885160 | 0.82 | GSK3B (0.42) | KDRPDGFRBHDAC1IDO1TDO2 | |
| SCHEMBL3209490 | 0.81 | AAK1 (0.46) | BRD4KDRPDGFRBKITHDAC1 | |
| SCHEMBL3220636 | 0.81 | MCL1 (0.47) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |