Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733680 | 0.90 | TRPV1 (0.51) | TRPV1CLK4OPRM1MEN1KMT2A | |
| SCHEMBL13613606 | 0.90 | TRPV1 (0.59) | TRPV1OPRM1 | |
| SCHEMBL13613635 | 0.89 | TRPV1 (0.54) | TRPV1OPRM1 | |
| SCHEMBL4344935 | 0.89 | TRPV1 (0.52) | TRPV1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13613685 | 0.89 | TRPV1 (0.52) | TRPV1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13613682 | 0.89 | TRPV1 (0.52) | TRPV1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2734515 | 0.89 | TRPV1 (0.50) | TRPV1OPRM1EPHX1 | |
| SCHEMBL13613609 | 0.89 | TRPV1 (0.51) | TRPV1OPRM1MEN1KMT2AALDH1A1 | |
| SCHEMBL13613612 | 0.89 | TRPV1 (0.55) | TRPV1OPRM1MEN1KMT2AALDH1A1 | |
| SCHEMBL13613650 | 0.89 | TRPV1 (0.51) | TRPV1OPRM1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |