Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029723 | 0.90 | GRM2 (0.56) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL12441933 | 0.89 | GRM2 (0.56) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL2025757 | 0.88 | GRM2 (0.55) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL2029663 | 0.88 | GRM2 (0.55) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL2022301 | 0.88 | GRM2 (0.47) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL1001497 | 0.88 | GRM2 (0.57) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL2025257 | 0.87 | GRM2 (0.46) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL2024263 | 0.87 | GRM2 (0.54) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL2022847 | 0.87 | GRM2 (0.54) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL2022287 | 0.86 | GRM2 (0.45) | GRM2ALDH1A1GRIN2BHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM3 | GRM2 4/4885ALDH1A1 1582/4885GRIN2B 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.