Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 17/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613655 | 0.93 | TRPV1 (0.56) | TRPV1RAB9A | |
| SCHEMBL13613711 | 0.89 | TRPV1 (0.61) | TRPV1RAB9ANPC1 | |
| SCHEMBL13613710 | 0.89 | TRPV1 (0.64) | TRPV1 | |
| SCHEMBL4336612 | 0.89 | TRPV1 (0.64) | TRPV1 | |
| SCHEMBL13613604 | 0.88 | TRPV1 (0.63) | TRPV1RAB9ANPC1 | |
| SCHEMBL206358 | 0.88 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL13613600 | 0.88 | TRPV1 (0.66) | TRPV1RAB9ANPC1POLB | |
| SCHEMBL13613602 | 0.88 | TRPV1 (0.62) | TRPV1RAB9ANPC1STING1 | |
| SCHEMBL4341397 | 0.88 | TRPV1 (0.69) | TRPV1RAB9ANPC1 | |
| SCHEMBL13613699 | 0.87 | TRPV1 (0.62) | TRPV1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |