Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 6/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14505294 | 1.00 | TLR7 (0.44) | TLR7LMNAPOLBHRH2ADRA1D | |
| SCHEMBL13613830 | 0.85 | TLR7 (0.44) | TLR7LMNAPOLBHRH2ADRA1D | |
| SCHEMBL13613829 | 0.83 | TLR7 (0.48) | TLR7LMNAPOLBHRH2ADRA1D | |
| SCHEMBL13613828 | 0.82 | TLR7 (0.55) | TLR7LMNAPOLBHRH2ADRA1D | |
| SCHEMBL13613802 | 0.81 | TLR7 (0.55) | TLR7TLR8 | |
| SCHEMBL13613838 | 0.80 | TLR7 (0.46) | TLR7LMNAPOLBHRH2ADRA1D | |
| SCHEMBL18588039 | 0.79 | TLR7 (0.52) | TLR7LMNAPOLBHRH2ADRA1D | |
| SCHEMBL4335984 | 0.78 | TLR7 (0.54) | TLR7LMNAPOLBHRH2ADRA1D | |
| SCHEMBL6280008 | 0.77 | TLR2 (0.39) | TLR2TLR1 | |
| SCHEMBL13613835 | 0.76 | KMT2A (0.46) | TLR7LMNAPOLBHRH2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612083-B2 | Urea substituted imidazoquinoline ethers | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612083-B2 | Urea substituted imidazoquinoline ethers | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2009-11-03 | — | — | US | disclosed |