Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696012 | 0.97 | MAP2K1 (0.42) | MAP2K1MAPTALOX15TSHR | |
| SCHEMBL694593 | 0.88 | MAP2K1 (0.44) | MAP2K1ALOX15TSHR | |
| SCHEMBL697138 | 0.88 | MAP2K1 (0.38) | MAP2K1MAPTALOX15TSHR | |
| SCHEMBL697078 | 0.84 | MAP2K1 (0.40) | MAP2K1MAPTALOX15TSHR | |
| SCHEMBL13148380 | 0.83 | MAP2K1 (0.51) | MAP2K1 | |
| SCHEMBL692646 | 0.83 | MAP2K1 (0.43) | MAP2K1MAPTALOX15TSHR | |
| SCHEMBL692714 | 0.81 | MAP2K1 (0.42) | MAP2K1 | |
| SCHEMBL693119 | 0.80 | MAP2K1 (0.45) | MAP2K1MAPT | |
| SCHEMBL695945 | 0.80 | MAP2K1 (0.42) | MAP2K1 | |
| SCHEMBL696986 | 0.80 | MAP2K1 (0.40) | MAP2K1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275606-A1 | Heterocyclic Compounds as MEK Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | disclosed |
| US-20090275606-A1 | Heterocyclic Compounds as MEK Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275606-A1 | Heterocyclic Compounds as MEK Inhibitors | NRAS, BRAF, MAP3K1 | MAP2K1 48/4885MAPT 3907/4885ALOX15 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.