Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848611 | 0.90 | MAPK14 (0.51) | MAPK14LCKNR1H4HPGDALDH1A1 | |
| SCHEMBL10950068 | 0.85 | MAPK14 (0.48) | MAPK14LCKNR1H4HPGDSMN1; SMN2 | |
| SCHEMBL4151138 | 0.82 | NR1H4 (0.61) | MAPK14NR1H4HPGDTAS1R3TAS1R1 | |
| SCHEMBL2809375 | 0.81 | MRGPRX4 (0.48) | HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL10953197 | 0.81 | SMN1; SMN2 (0.44) | MAPK14HPGDCA12CA9SMN1; SMN2 | |
| SCHEMBL15337170 | 0.80 | PPARG (0.51) | MAPK14HPGDCA12CA9MAPT | |
| SCHEMBL18661954 | 0.79 | MAPK14 (0.51) | MAPK14LCKNR1H4HPGDSMN1; SMN2 | |
| SCHEMBL3250190 | 0.78 | MAPT (0.59) | MAPK14LCKNR1H4HPGDSMN1; SMN2 | |
| SCHEMBL12958467 | 0.78 | MAPK14 (0.50) | MAPK14LCKNR1H4HPGDALDH1A1 | |
| SCHEMBL13265891 | 0.78 | KDM4E (0.58) | MAPK14HPGDMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |