Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888880 | 0.80 | SYK (0.46) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| SCHEMBL1887992 | 0.80 | SYK (0.46) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| SCHEMBL2390949 | 0.77 | SYK (0.44) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| SCHEMBL2389685 | 0.71 | MAPKAPK5 (0.64) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| Glpg-0259 SCHEMBL1889564 | 0.71 | MAPKAPK5 (0.49) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| Glpg-0259 SCHEMBL12661679 | 0.71 | MAPKAPK5 (0.49) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| SCHEMBL2390977 | 0.71 | SYK (0.40) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| SCHEMBL2387713 | 0.71 | SYK (0.43) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| SCHEMBL1570305 | 0.70 | SYK (0.43) | SYKMAPKAPK5TLR9TLR8TLR7 | |
| SCHEMBL2394082 | 0.69 | MAPKAPK5 (0.47) | SYKMAPKAPK5TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135885-A1 | FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-11-12 | — | — | WO | disclosed |