Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.46 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776709 | 0.90 | MAP2K1 (0.64) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL1775329 | 0.88 | MAP2K1 (0.67) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL218952 | 0.81 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3800930 | 0.80 | MAP2K1 (0.59) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL12274474 | 0.80 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL1775100 | 0.79 | MAP2K1 (0.72) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL12274766 | 0.79 | MAP2K1 (0.55) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL4755503 | 0.77 | MAP2K1 (0.69) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL16323082 | 0.77 | MAP2K1 (0.55) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL12600067 | 0.77 | MAP2K1 (0.67) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2113500-A1 | MAPK/ERK kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2009-11-04 | — | — | EP | disclosed |