Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | DUT | P33316 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845473 | 0.91 | SMN1; SMN2 (0.43) | POLBSMN1; SMN2ALDH1A1GAATHRB | |
| SCHEMBL3845471 | 0.91 | SMN1; SMN2 (0.43) | POLBSMN1; SMN2ALDH1A1GAATHRB | |
| SCHEMBL6784313 | 0.78 | POLB (0.50) | POLBSMN1; SMN2ALDH1A1TSHRGAA | |
| SCHEMBL14286704 | 0.77 | TDP1 (0.53) | SMN1; SMN2ALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL10932475 | 0.76 | CETP (0.35) | POLBSMN1; SMN2ALDH1A1GAAKMT2A | |
| SCHEMBL15778088 | 0.75 | POLB (0.52) | POLBSMN1; SMN2ALDH1A1TSHRGAA | |
| SCHEMBL1759186 | 0.74 | POLB (0.46) | POLBALDH1A1TSHRGAAL3MBTL1 | |
| SCHEMBL10847001 | 0.73 | POLB (0.41) | POLBALDH1A1TSHRKMT2A | |
| SCHEMBL8616386 | 0.73 | TDP1 (0.49) | POLBSMN1; SMN2ALDH1A1TSHRGAA | |
| SCHEMBL1239980 | 0.73 | POLB (0.52) | POLBSMN1; SMN2ALDH1A1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311488-B1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | PFIZER LTD (GB) | 2009-11-04 | — | — | EP | disclosed |