Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.65 |
| ▸ | EGFR | P00533 | 13/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.56 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 2/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6461603 | 0.94 | KDR (0.58) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL6461611 | 0.88 | KDR (0.51) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL1614506 | 0.88 | KDR (0.75) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL13617346 | 0.86 | KDR (0.61) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL1781194 | 0.86 | KDR (0.67) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL12604713 | 0.83 | RET (0.63) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL1781457 | 0.81 | KDR (0.58) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL2055590 | 0.80 | KDR (0.75) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL16596259 | 0.79 | DNMT1 (0.59) | KDRFLT1FLT4PDGFRBPDGFRA | |
| SCHEMBL13617552 | 0.79 | KDR (0.75) | KDREGFRRETFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943240-B1 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2009-11-11 | — | — | EP | disclosed |