Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.62 |
| ▸ | BRAF | P15056 | 14/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893595 | 0.90 | RAF1 (0.63) | RAF1BRAFKDREPHX2 | |
| SCHEMBL2887052 | 0.89 | BRAF (0.72) | RAF1BRAFKDREPHX2 | |
| SCHEMBL2890468 | 0.87 | RAF1 (0.58) | RAF1BRAFKDREPHX2 | |
| SCHEMBL13618024 | 0.86 | RAF1 (0.63) | RAF1BRAFKDR | |
| SCHEMBL2892461 | 0.84 | BRAF (0.68) | RAF1BRAFKDREPHX2 | |
| SCHEMBL13209730 | 0.84 | RAF1 (0.65) | RAF1BRAFKDR | |
| SCHEMBL2893930 | 0.83 | RAF1 (0.67) | RAF1BRAFKDR | |
| SCHEMBL2895388 | 0.83 | RAF1 (0.70) | RAF1BRAFKDR | |
| SCHEMBL2891608 | 0.83 | RAF1 (0.72) | RAF1BRAFKDREPHX2 | |
| SCHEMBL2891998 | 0.83 | RAF1 (0.72) | RAF1BRAFKDREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |