Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.54 |
| ▸ | BRAF | P15056 | 10/20 | 0.54 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893386 | 0.92 | RAF1 (0.64) | RAF1BRAFKDR | |
| SCHEMBL13210278 | 0.86 | RAF1 (0.63) | RAF1BRAFP2RX3KDR | |
| SCHEMBL13210202 | 0.86 | RAF1 (0.75) | RAF1BRAFKDR | |
| SCHEMBL2893229 | 0.84 | RAF1 (0.61) | RAF1BRAFSCN9AKDR | |
| SCHEMBL13838702 | 0.84 | RAF1 (0.61) | RAF1BRAFKDR | |
| SCHEMBL2892774 | 0.83 | RAF1 (0.62) | RAF1BRAFKDR | |
| SCHEMBL2890457 | 0.83 | RAF1 (0.63) | RAF1BRAFKDRSMN1; SMN2 | |
| SCHEMBL13211302 | 0.82 | BRAF (0.58) | RAF1BRAFSCN9AKDR | |
| SCHEMBL13504221 | 0.82 | BRAF (0.57) | RAF1BRAFKDR | |
| SCHEMBL2892113 | 0.82 | RAF1 (0.68) | RAF1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |