Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.58 |
| ▸ | BRAF | P15056 | 15/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | ROS1 | P08922 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845288 | 0.86 | BRAF (0.70) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2895137 | 0.81 | RAF1 (0.76) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13719454 | 0.78 | BRAF (0.72) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13838695 | 0.77 | RAF1 (0.67) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13210289 | 0.76 | RAF1 (0.79) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2892682 | 0.75 | RAF1 (0.60) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2885904 | 0.75 | BRAF (0.72) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13209869 | 0.75 | BRAF (0.78) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2889830 | 0.74 | BRAF (1.00) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2892492 | 0.74 | RAF1 (0.70) | RAF1BRAFKDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |