Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13618628 | 0.88 | TSHR (0.64) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL4059758 | 0.88 | TSHR (0.64) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL4102493 | 0.86 | TSHR (0.62) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL1764373 | 0.86 | TSHR (0.62) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL10181988 | 0.86 | TSHR (0.62) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL12052569 | 0.86 | TSHR (0.66) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL10181902 | 0.85 | TSHR (0.64) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL1764374 | 0.85 | TSHR (0.61) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL13091199 | 0.85 | TSHR (0.67) | TSHRHTTPOLBTP53PLK1 | |
| SCHEMBL89401 | 0.84 | TSHR (0.71) | TSHRHTTPOLBTP53PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |