Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.68 |
| ▸ | BRAF | P15056 | 19/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | STK25 | O00506 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | PAK3 | O75914 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895305 | 0.90 | RAF1 (0.71) | RAF1BRAFKDR | |
| SCHEMBL13838689 | 0.88 | RAF1 (0.66) | RAF1BRAFKDRSTK25CIT | |
| SCHEMBL2895248 | 0.87 | RAF1 (0.67) | RAF1BRAFKDR | |
| SCHEMBL13211124 | 0.87 | RAF1 (0.67) | RAF1BRAFKDR | |
| SCHEMBL2895251 | 0.87 | RAF1 (0.67) | RAF1BRAFKDR | |
| SCHEMBL13211138 | 0.86 | RAF1 (0.64) | RAF1BRAFKDRSTK25CIT | |
| SCHEMBL13211387 | 0.86 | RAF1 (0.72) | RAF1BRAFKDR | |
| SCHEMBL3125119 | 0.84 | RAF1 (0.68) | RAF1BRAFKDR | |
| SCHEMBL2906212 | 0.84 | RAF1 (0.70) | RAF1BRAFKDRSTK25CIT | |
| SCHEMBL2901751 | 0.82 | RAF1 (0.71) | RAF1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |