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Sugi Predict / Compounds / SCHEMBL13618155

SCHEMBL13618155

SCHEMBL13618155

C=Cc1ccc(Nc2nc3cc(Oc4ccnc(C(=O)Nc5ccccc5)c4)ccc3n2C)cc1

nearest known ligand 0.73

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 18/20 0.73
▸ RAF1 P04049 17/20 0.73
▸ LCK P06239 1/20 0.59
▸ FYN P06241 1/20 0.59
▸ PDGFRB P09619 1/20 0.59
▸ KIT P10721 1/20 0.59
▸ FLT1 P17948 1/20 0.59
▸ FLT4 P35916 1/20 0.59
▸ KDR P35968 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2890246 0.89 RAF1 (0.80) BRAFRAF1LCKFYNPDGFRB
SCHEMBL13618558 0.85 BRAF (0.70) BRAFRAF1LCKFYNPDGFRB
SCHEMBL13211164 0.85 BRAF (0.86) BRAFRAF1LCKFYNPDGFRB
SCHEMBL2894951 0.85 RAF1 (1.00) BRAFRAF1LCKFYNPDGFRB
SCHEMBL2892845 0.83 RAF1 (0.93) BRAFRAF1LCKFYNPDGFRB
SCHEMBL13617987 0.82 RAF1 (0.61) BRAFRAF1LCKFYNPDGFRB
SCHEMBL13211177 0.82 BRAF (0.80) BRAFRAF1LCKFYNPDGFRB
SCHEMBL13618355 0.81 RAF1 (0.61) BRAFRAF1LCKFYNPDGFRB
SCHEMBL13211178 0.81 RAF1 (0.75) BRAFRAF1LCKFYNPDGFRB
SCHEMBL13617991 0.81 BRAF (0.67) BRAFRAF1LCKFYNPDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1499311-B1 SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS NOVARTIS VACCINES & DIAGNOSTIC (US) 2009-11-04 — — EP disclosed