Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 19/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12645937 | 0.82 | LCK (0.65) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL13983630 | 0.79 | AURKB (0.70) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL13618186 | 0.78 | AURKB (0.70) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL14533851 | 0.76 | AURKB (0.47) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL14538362 | 0.74 | LCK (0.46) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL13899609 | 0.71 | AURKA (0.49) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL13899630 | 0.68 | AURKB (0.51) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL13899549 | 0.68 | AURKB (0.46) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL13899514 | 0.68 | AURKB (0.44) | LCKAURKBCHEK1KDRIRAK4 | |
| SCHEMBL13899568 | 0.68 | AURKB (0.44) | LCKAURKBCHEK1KDRIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137378-A2 | SEQUENTIAL ADMINISTRATION OF CHEMOTHERAPEUTIC AGENTS FOR TREATMENT OF CANCER | SCHERING CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |