Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.83 |
| ▸ | RAF1 | P04049 | 15/20 | 0.83 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886999 | 0.91 | BRAF (1.00) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL2893265 | 0.89 | BRAF (0.80) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL13618558 | 0.88 | BRAF (0.70) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL2890953 | 0.87 | BRAF (0.77) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL2887008 | 0.87 | BRAF (0.77) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL2895177 | 0.86 | BRAF (0.76) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL13618591 | 0.84 | BRAF (0.73) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL13559467 | 0.84 | BRAF (0.73) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL2889849 | 0.83 | BRAF (0.71) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL2892790 | 0.83 | BRAF (0.73) | BRAFRAF1LCKFYNPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |