SCHEMBL13618771

SCHEMBL13618771

CCC/C=C/c1cccs1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.48
MAPT P10636 1/20 0.46
HTT P42858 1/20 0.46
TAS1R3 Q7RTX0 1/20 0.45
TAS1R1 Q7RTX1 1/20 0.45
ALOX5 P09917 3/20 0.43
PTGS1 P23219 3/20 0.43
PTGS2 P35354 3/20 0.43
RAB9A P51151 2/20 0.43
KMT2A Q03164 1/20 0.43
CYP1A1 P04798 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP1B1 Q16678 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
HPGD P15428 1/20 0.41
LMNA P02545 2/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3688382 0.89 MAPT (0.51) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL20634195 0.89 MAPT (0.51) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL21392011 0.89 MAPT (0.51) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL23671882 0.87 HCAR2 (0.44) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL23671875 0.87 HCAR2 (0.44) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL6434876 0.87 MAPT (0.50) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL6434868 0.87 MAPT (0.50) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL2007435 0.85 MAPT (0.49) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL23345517 0.85 MAPT (0.49) HCAR2MAPTHTTTAS1R3TAS1R1
SCHEMBL16135275 0.85 MAPT (0.49) HCAR2MAPTHTTTAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9591935-B2 Therapeutic substituted cyclopentanes ALLERGEN, INC. (US) 2017-03-14 US disclosed
WO-2009137413-A1 THERAPEUTIC CYCLOPENTANE DERIVATIVES ALLERGAN, INC. (US) 2009-11-12 WO disclosed