Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | WHR1 | P49842 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472453 | 0.79 | WHR1 (0.47) | WHR1PDE4APDE4DEGFRERBB2 | |
| SCHEMBL3469786 | 0.78 | FGFR2 (0.43) | PDE10AWHR1PDE4APDE4DEGFR | |
| SCHEMBL3472098 | 0.76 | PDE4A (0.62) | WHR1PDE4APDE4DEGFRERBB2 | |
| SCHEMBL3469902 | 0.74 | WHR1 (0.51) | WHR1PDE4APDE4DEGFRLMNA | |
| SCHEMBL3471427 | 0.74 | WHR1 (0.51) | WHR1PDE4APDE4DEGFRERBB2 | |
| SCHEMBL3470966 | 0.73 | WHR1 (0.50) | WHR1PDE4APDE4DEGFRERBB2 | |
| SCHEMBL3470056 | 0.71 | ERBB2 (0.48) | WHR1PDE4APDE4DEGFRERBB2 | |
| SCHEMBL3471534 | 0.71 | PDE4A (0.52) | PDE10AWHR1PDE4APDE4DEGFR | |
| SCHEMBL3470960 | 0.70 | WHR1 (0.45) | PDE10AWHR1PDE4APDE4DEGFR | |
| SCHEMBL3470198 | 0.70 | KRAS (0.47) | PDE10AWHR1PDE4APDE4DEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401451-B1 | QUINAZOLINE DERIVATIVES WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |