Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871615 | 1.00 | DDB1 (0.40) | DDB1CRBNTLR9TLR8TLR7 | |
| SCHEMBL8262288 | 1.00 | DDB1 (0.40) | DDB1CRBNTLR9TLR8TLR7 | |
| SCHEMBL31122203 | 0.76 | DDB1 (0.51) | DDB1CRBN | |
| SCHEMBL25693522 | 0.75 | DDB1 (0.44) | DDB1CRBN | |
| Hydrochloric Acid SCHEMBL31210159 | 0.74 | DDB1 (0.50) | DDB1CRBN | |
| SCHEMBL1095482 | 0.72 | DDB1 (0.45) | DDB1CRBN | |
| Hydrochloric Acid SCHEMBL3882894 | 0.71 | DDB1 (0.44) | DDB1CRBN | |
| SCHEMBL3879144 | 0.70 | DDB1 (0.43) | DDB1CRBNIDH1 | |
| SCHEMBL3885452 | 0.68 | DDB1 (0.41) | DDB1CRBNIDH1 | |
| SCHEMBL3872150 | 0.68 | DDB1 (0.41) | DDB1CRBNIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848694-B1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | HOFFMANN LA ROCHE (CH) | 2009-11-25 | — | — | EP | disclosed |