Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155981 | 1.00 | TSHR (0.47) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL28576041 | 1.00 | TSHR (0.47) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL29093375 | 1.00 | TSHR (0.47) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL29093179 | 1.00 | TSHR (0.47) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL28576200 | 1.00 | TSHR (0.47) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL6285447 | 0.96 | TRPV1 (0.50) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL17002461 | 0.96 | TRPV1 (0.50) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL7757768 | 0.96 | TRPV1 (0.50) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL4443550 | 0.96 | TRPV1 (0.50) | TSHRTDP1TRPV1TRPA1ALDH1A1 | |
| SCHEMBL5136479 | 0.96 | TRPV1 (0.50) | TSHRTDP1TRPV1TRPA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615543-B2 | Complexes with C-reactive protein (CRP) molecules; rheumatoid arthritis, juvenile chronic (rheumatoid) arthritis, ankylosing spondylitis, psoriatic arthritis, systemic vasculitis, polymyalgia rheumatica, Reiter's disease, Crohn's disease and familial Mediterranean fever | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |
| US-7615543-B2 | Complexes with C-reactive protein (CRP) molecules; rheumatoid arthritis, juvenile chronic (rheumatoid) arthritis, ankylosing spondylitis, psoriatic arthritis, systemic vasculitis, polymyalgia rheumatica, Reiter's disease, Crohn's disease and familial Mediterranean fever | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |