SCHEMBL13619723

SCHEMBL13619723

COC(=O)c1cc(I)c(F)cc1C(C)=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.45
SOS1 Q07889 1/20 0.40
ALDH1A1 P00352 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA7 P43166 2/20 0.36
CA9 Q16790 2/20 0.36
CA14 Q9ULX7 2/20 0.36
PDK2 Q15119 1/20 0.36
PDK4 Q16654 1/20 0.36
KDM4E B2RXH2 5/20 0.35
GAA P10253 3/20 0.35
LMNA P02545 2/20 0.35
POLB P06746 1/20 0.35
NFKB1 P19838 1/20 0.35
XDH P47989 1/20 0.35
GFER P55789 1/20 0.35
NFKB2 Q00653 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3872035 0.93 CFTR (0.50) CFTRSOS1ALDH1A1L3MBTL1CA12
SCHEMBL11922634 0.84 CFTR (0.49) CFTRSOS1ALDH1A1L3MBTL1CA12
SCHEMBL15543856 0.81 CFTR (0.46) CFTRSOS1ALDH1A1L3MBTL1CA12
SCHEMBL7082612 0.79 GAA (0.46) CFTRSOS1ALDH1A1GAALMNA
SCHEMBL13814561 0.79 CFTR (0.60) CFTRSOS1ALDH1A1KDM4EGAA
SCHEMBL24801995 0.79 SOS1 (0.47) SOS1ALDH1A1L3MBTL1CA12CA1
SCHEMBL29568744 0.79 CFTR (0.60) CFTRSOS1ALDH1A1KDM4EGAA
SCHEMBL1300753 0.79 GAA (0.49) CFTRSOS1ALDH1A1KDM4EGAA
SCHEMBL23526138 0.79 SOS1 (0.47) SOS1ALDH1A1L3MBTL1CA12CA1
SCHEMBL16155019 0.79 CFTR (0.65) CFTRSOS1ALDH1A1KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1848694-B1 HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 HOFFMANN LA ROCHE (CH) 2009-11-25 EP disclosed