Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532846 | 0.86 | PARP1 (0.42) | HDAC9DPP9DPP7PARP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9174977 | 0.85 | PARP1 (0.41) | HDAC9DPP9DPP7PARP1ALDH1A1 | |
| SCHEMBL122942 | 0.82 | HDAC9 (0.44) | HDAC9DPP9DPP7MMEMMP8 | |
| SCHEMBL29476532 | 0.82 | HDAC9 (0.44) | HDAC9DPP9DPP7MMEMMP8 | |
| SCHEMBL12571286 | 0.80 | NOTUM (0.42) | HDAC9DPP9DPP7PARP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1168670 | 0.80 | HDAC9 (0.43) | HDAC9DPP9DPP7MMEMMP8 | |
| Hydrochloric Acid SCHEMBL11790216 | 0.78 | HDAC9 (0.38) | HDAC9DPP9DPP7PARP1KDM4E | |
| SCHEMBL30556973 | 0.78 | DPP8 (0.35) | DPP9PARP1KDM4ETDP1 | |
| SCHEMBL2055554 | 0.76 | BRD4 (0.41) | HDAC9ALDH1A1POLBL3MBTL1NOTUM | |
| SCHEMBL22729870 | 0.75 | MEN1 (0.42) | HDAC9DPP9DPP7MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135590-A1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2009-11-12 | — | — | WO | disclosed |
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |