Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.76 |
| ▸ | CDK8 | P49336 | 1/20 | 0.76 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.76 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.73 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.67 |
| ▸ | SGK1 | O00141 | 6/20 | 0.66 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.65 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.62 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298162 | 0.88 | MAPK8 (0.72) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL12763531 | 0.88 | NTRK1 (0.84) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL8320902 | 0.88 | MAPK8 (0.67) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL8941685 | 0.87 | AXL (1.00) | AXLCDK8TNIKMAPK8NTRK1 | |
| SCHEMBL8256110 | 0.85 | MAPK8 (0.64) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL8258597 | 0.85 | MAPK8 (0.70) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL4406366 | 0.85 | MAPK8 (1.00) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL1487584 | 0.83 | CDK8 (0.72) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL13745264 | 0.83 | CDK8 (0.72) | AXLCDK8TNIKMAPK8MAPK9 | |
| SCHEMBL8319981 | 0.83 | MAPK8 (0.67) | AXLCDK8TNIKMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612086-B2 | Jun N-terminal kinase inhibitors; 1H-pyrrolo[2,3-b]pyridines 3-substituted with a C 5-7 carbocycle and 5-substituted by a 5-member heterocycle; 3-(p-(dimethylamino)phenyl)-5-(2-thiazolyl-1H-pyrrolo[2,3-b]pyridine; neurodegenerative disorders related to apoptosis and/or inflammation | EISAI R & D MANAGEMENT CO. LTD. (JP) | 2009-11-03 | — | — | US | disclosed |