Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654169 | 1.00 | CCR1 (0.70) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL654168 | 1.00 | CCR1 (0.70) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10288262 | 0.93 | CCR1 (0.81) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL12121887 | 0.93 | CCR1 (0.70) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10288240 | 0.93 | CCR1 (0.81) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL655101 | 0.90 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL13620884 | 0.90 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL655100 | 0.90 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL652537 | 0.89 | CCR1 (0.69) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL13620897 | 0.89 | CCR1 (0.69) | CCR1CHRM2CCR5HRH1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | MILLENNIUM PHARMACEUTICALS INC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | MILLENNIUM PHARMACEUTICALS INC. (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | CCR1, CCR3, CCR4 | CCR1 1/4885CHRM2 4457/4885CCR5 12/4885 |
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | CCR1, CCR3, CCR4 | CCR1 1/4885CHRM2 4696/4885CCR5 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.