Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.42 |
| ▸ | HTR1A | P08908 | 8/20 | 0.42 |
| ▸ | DRD2 | P14416 | 8/20 | 0.42 |
| ▸ | DRD4 | P21917 | 8/20 | 0.42 |
| ▸ | HTR2A | P28223 | 8/20 | 0.42 |
| ▸ | HTR2C | P28335 | 8/20 | 0.42 |
| ▸ | HTR7 | P34969 | 8/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.42 |
| ▸ | DRD3 | P35462 | 7/20 | 0.42 |
| ▸ | HTR2B | P41595 | 7/20 | 0.42 |
| ▸ | HTR1D | P28221 | 7/20 | 0.42 |
| ▸ | HRH2 | P25021 | 6/20 | 0.42 |
| ▸ | DRD1 | P21728 | 6/20 | 0.42 |
| ▸ | DRD5 | P21918 | 6/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655101 | 0.92 | CCR1 (0.72) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL13620884 | 0.92 | CCR1 (0.72) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL655100 | 0.92 | CCR1 (0.72) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL14703481 | 0.91 | CCR1 (0.71) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL10288262 | 0.89 | CCR1 (0.81) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL10288240 | 0.89 | CCR1 (0.81) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL12121887 | 0.88 | CCR1 (0.70) | CCR1CHRM2CCR5HTR1ADRD2 | |
| SCHEMBL13620896 | 0.87 | CCR1 (0.66) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL655292 | 0.87 | CCR1 (0.66) | CCR1OPRM1OPRL1CHRM2CCR5 | |
| SCHEMBL655291 | 0.87 | CCR1 (0.66) | CCR1OPRM1OPRL1CHRM2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | MILLENNIUM PHARMACEUTICALS INC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | MILLENNIUM PHARMACEUTICALS INC. (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | CCR1, CCR3, CCR4 | CCR1 1/4885OPRM1 3631/4885OPRL1 1945/4885 |
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | CCR1, CCR3, CCR4 | CCR1 1/4885OPRM1 3656/4885OPRL1 2325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.