SCHEMBL13622950 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NTRK1	P04629	10/20	0.45

▸	NTRK3	Q16288	9/20	0.45

▸	NTRK2	Q16620	9/20	0.45

▸	FYN	P06241	8/20	0.42

▸	JAK2	O60674	2/20	0.39

▸	INSR	P06213	2/20	0.39

▸	LYN	P07948	2/20	0.39

▸	RET	P07949	2/20	0.39

▸	MET	P08581	2/20	0.39

▸	ROS1	P08922	2/20	0.39

▸	FGR	P09769	2/20	0.39

▸	KIT	P10721	2/20	0.39

▸	FGFR4	P22455	2/20	0.39

▸	FGFR3	P22607	2/20	0.39

▸	TIE1	P35590	2/20	0.39

▸	KDR	P35968	2/20	0.39

▸	FLT3	P36888	2/20	0.39

▸	ALK	Q9UM73	2/20	0.39

▸	ABL1	P00519	1/20	0.39

▸	LCK	P06239	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1430849	0.88	NTRK1 (0.59)	NTRK1NTRK3NTRK2FYNJAK2
SCHEMBL13622991	0.73	NTRK1 (0.79)	NTRK1NTRK3NTRK2JAK2INSR
SCHEMBL13623584	0.73	NTRK1 (0.79)	NTRK1NTRK3NTRK2JAK2INSR
SCHEMBL13623593	0.72	NTRK1 (0.79)	NTRK1NTRK3NTRK2JAK2INSR
SCHEMBL13623601	0.72	NTRK1 (0.79)	NTRK1NTRK3NTRK2JAK2INSR
SCHEMBL13623596	0.72	NTRK1 (0.79)	NTRK1NTRK3NTRK2JAK2INSR
SCHEMBL2238233	0.68	NTRK1 (0.64)	NTRK1JAK2
SCHEMBL13622993	0.67	NTRK1 (0.66)	NTRK1
SCHEMBL13622994	0.67	NTRK1 (0.66)	NTRK1
SCHEMBL13622962	0.65	NTRK1 (0.75)	NTRK1NTRK3NTRK2FYNJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009140128-A2	COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS	IRM LLC (BM)	2009-11-19	—	—	WO	disclosed