Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 6/20 | 0.56 |
| ▸ | METAP2 | P50579 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363565 | 1.00 | METAP1 (0.56) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4367511 | 1.00 | METAP1 (0.56) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4366699 | 0.91 | METAP1 (0.54) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4368578 | 0.89 | METAP1 (0.58) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4367996 | 0.88 | METAP1 (0.60) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4368728 | 0.87 | METAP1 (0.59) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4369556 | 0.87 | METAP1 (0.56) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4371250 | 0.85 | METAP1 (0.58) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4371979 | 0.84 | METAP1 (0.55) | METAP1METAP2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4367716 | 0.84 | METAP1 (0.55) | METAP1METAP2ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622592-B2 | Carbonylamino-benzimidazole derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622592-B2 | Carbonylamino-benzimidazole derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-11-24 | — | — | US | disclosed |