Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 2/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 6/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366820 | 0.89 | METAP1 (0.45) | MAPTSMN1; SMN2CRHBPCRHR2GAA | |
| SCHEMBL13624164 | 0.88 | METAP1 (0.50) | SMN1; SMN2RAB9ALMNACA12CA1 | |
| SCHEMBL4379262 | 0.88 | METAP1 (0.50) | SMN1; SMN2RAB9ACA12CA1CA2 | |
| SCHEMBL13624163 | 0.88 | METAP1 (0.50) | SMN1; SMN2RAB9ALMNACA12CA1 | |
| SCHEMBL4379056 | 0.88 | METAP1 (0.50) | SMN1; SMN2RAB9ALMNACA12CA1 | |
| SCHEMBL4367982 | 0.88 | METAP1 (0.50) | SMN1; SMN2RAB9ACA12CA1CA2 | |
| SCHEMBL4366074 | 0.88 | METAP1 (0.50) | SMN1; SMN2RAB9ACA12CA1CA2 | |
| SCHEMBL4366722 | 0.85 | METAP1 (0.55) | MAPTSMN1; SMN2CRHBPCRHR2GAA | |
| SCHEMBL4368752 | 0.82 | KDR (0.46) | MAPTSMN1; SMN2RAB9AMETAP1METAP2 | |
| SCHEMBL4368578 | 0.81 | METAP1 (0.58) | MAPTSMN1; SMN2RAB9ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622592-B2 | Carbonylamino-benzimidazole derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622592-B2 | Carbonylamino-benzimidazole derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-11-24 | — | — | US | disclosed |