Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15766209 | 0.88 | KDM4E (0.76) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL13699674 | 0.88 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL28834775 | 0.87 | KDM4E (0.79) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL18412928 | 0.78 | MAPT (0.49) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL20534963 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL1849885 | 0.76 | KDM4E (0.76) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL6243382 | 0.74 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL10372134 | 0.74 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL27283285 | 0.74 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL4762078 | 0.74 | KDM4E (1.00) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622582-B2 | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one | TIBOTEC BVBA (BE) | 2009-11-24 | — | — | US | disclosed |
| US-7622582-B2 | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one | TIBOTEC BVBA (BE) | 2009-11-24 | — | — | US | disclosed |
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC BVBA (BE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC BVBA (BE) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | NR2C2, CYP4B1, OXER1 | KDM4E 3819/4885ALDH1A1 1060/4885SMN1; SMN2 4217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.