Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 16/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12593775 | 0.90 | CYP2C9 (0.50) | CYP2C9CYP3A4CCR2TSHRCYP2C19 | |
| SCHEMBL10222966 | 0.90 | CYP2C9 (0.50) | CYP2C9CYP3A4CCR2TSHRCYP2C19 | |
| SCHEMBL10272191 | 0.85 | CYP2C9 (0.57) | CYP2C9CYP3A4CCR2 | |
| SCHEMBL305588 | 0.84 | CYP2C9 (0.61) | CYP2C9CYP3A4CCR2TSHR | |
| SCHEMBL12648765 | 0.84 | CYP2C9 (0.55) | CYP2C9CYP3A4CCR2TSHR | |
| SCHEMBL13623789 | 0.84 | CYP2C9 (0.61) | CYP2C9CYP3A4CCR2 | |
| SCHEMBL10272154 | 0.83 | CYP2C9 (0.52) | CYP2C9CYP3A4CCR2 | |
| SCHEMBL306918 | 0.79 | CYP2C9 (0.58) | CYP2C9CYP3A4CCR2TSHRCYP2C19 | |
| SCHEMBL306540 | 0.79 | CYP2C9 (0.61) | CYP2C9CYP3A4CCR2TSHRCYP2C19 | |
| SCHEMBL307531 | 0.78 | CYP2C9 (0.63) | CYP2C9CYP3A4CCR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622583-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2009-11-24 | — | — | US | disclosed |