Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.79 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1354050 | 0.90 | SYK (0.78) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1354018 | 0.89 | SYK (1.00) | SYK | |
| SCHEMBL1353363 | 0.88 | SYK (1.00) | SYK | |
| SCHEMBL1353235 | 0.87 | SYK (1.00) | SYK | |
| SCHEMBL1354394 | 0.87 | SYK (0.84) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1352100 | 0.86 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1351780 | 0.86 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14038888 | 0.85 | SYK (0.84) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1354235 | 0.85 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1352154 | 0.85 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |