Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.67 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.67 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2627318 | 0.88 | SYK (0.72) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL2385591 | 0.86 | SYK (0.69) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL764204 | 0.85 | SYK (0.71) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL10241903 | 0.84 | SYK (0.70) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL14659023 | 0.84 | SYK (0.72) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL29761550 | 0.84 | SYK (0.72) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL16782347 | 0.81 | SYK (0.66) | SYKAURKBKCNH2ZAP70 | |
| SCHEMBL763269 | 0.81 | SYK (0.69) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL15161258 | 0.81 | SYK (0.69) | SYKAURKBKCNH2ZAP70MAPK3 | |
| SCHEMBL763624 | 0.81 | SYK (0.69) | SYKAURKBKCNH2ZAP70MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323993-B1 | 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | PORTOLA PHARM INC (US) | 2015-06-03 | — | — | EP | disclosed |
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |