Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1354749 | 0.82 | SYK (1.00) | SYK | |
| SCHEMBL1354753 | 0.82 | SYK (1.00) | SYK | |
| SCHEMBL1853650 | 0.81 | SYK (0.72) | SYK | |
| SCHEMBL1354090 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL1354085 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL737832 | 0.78 | SYK (0.92) | SYK | |
| SCHEMBL13624653 | 0.78 | SYK (0.64) | SYKMAPK8ZAP70STAT6 | |
| SCHEMBL1353570 | 0.78 | SYK (1.00) | SYKKCNH2AURKB | |
| SCHEMBL13624871 | 0.78 | SYK (0.67) | SYKMAPK8ZAP70KCNH2AURKB | |
| SCHEMBL735941 | 0.77 | SYK (1.00) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |