Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 1.00 |
| ▸ | LCK | P06239 | 1/20 | 1.00 |
| ▸ | YES1 | P07947 | 1/20 | 1.00 |
| ▸ | LYN | P07948 | 1/20 | 1.00 |
| ▸ | FGR | P09769 | 1/20 | 1.00 |
| ▸ | SRC | P12931 | 1/20 | 1.00 |
| ▸ | PRKCA | P17252 | 1/20 | 1.00 |
| ▸ | FLT3 | P36888 | 1/20 | 1.00 |
| ▸ | ZAP70 | P43403 | 1/20 | 1.00 |
| ▸ | MAP3K9 | P80192 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | PAK5 | Q9P286 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899872 | 1.00 | SYK (1.00) | SYKJAK2LCKYES1LYN | |
| SCHEMBL1352147 | 1.00 | SYK (1.00) | SYKJAK2LCKYES1LYN | |
| SCHEMBL14977351 | 1.00 | SYK (1.00) | SYKJAK2LCKYES1LYN | |
| SCHEMBL1353814 | 1.00 | SYK (1.00) | SYKJAK2LCKYES1LYN | |
| SCHEMBL900582 | 1.00 | SYK (1.00) | SYKJAK2LCKYES1LYN | |
| Hydrochloric Acid SCHEMBL29392320 | 0.99 | SYK (0.98) | SYKJAK2LCKYES1LYN | |
| Hydrochloric Acid SCHEMBL900878 | 0.99 | SYK (0.98) | SYKJAK2LCKYES1LYN | |
| SCHEMBL1353568 | 0.98 | SYK (1.00) | SYKJAK2LCKYES1LYN | |
| SCHEMBL1353566 | 0.98 | SYK (1.00) | SYKJAK2LCKYES1LYN | |
| SCHEMBL1353462 | 0.98 | SYK (1.00) | SYKJAK2LCKYES1LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323993-B1 | 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | PORTOLA PHARM INC (US) | 2015-06-03 | — | — | EP | disclosed |
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |