Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 3/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1227632 | 1.00 | MERTK (0.49) | MERTKLRRK2CHUKMAPK8PRKCQ | |
| SCHEMBL1227635 | 1.00 | MERTK (0.49) | MERTKLRRK2CHUKMAPK8PRKCQ | |
| SCHEMBL1227640 | 1.00 | MERTK (0.49) | MERTKLRRK2CHUKMAPK8PRKCQ | |
| SCHEMBL14656110 | 0.93 | MERTK (0.43) | MERTKLRRK2MAPK8JAK3JAK2 | |
| SCHEMBL14657460 | 0.87 | MAPK8 (0.42) | MERTKLRRK2CHUKMAPK8PRKCQ | |
| SCHEMBL28455414 | 0.84 | MAPK8 (0.37) | MERTKMAPK8JAK3JAK2CYP2C9 | |
| SCHEMBL1226660 | 0.83 | LRRK2 (0.44) | MERTKLRRK2CHUKPRKCQKDM4E | |
| SCHEMBL1227148 | 0.83 | MEN1 (0.47) | MERTKLRRK2CHUKPRKCQKDM4E | |
| SCHEMBL16822051 | 0.82 | PRKCQ (0.53) | MERTKLRRK2CHUKPRKCQPRKCD | |
| SCHEMBL16822047 | 0.82 | PRKCQ (0.53) | MERTKLRRK2CHUKPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132980-A1 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK. | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-05 | — | — | WO | disclosed |