Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197684 | 0.86 | BRAF (0.59) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL13625136 | 0.85 | BRAF (0.58) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL13625184 | 0.81 | BRAF (0.54) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL12350014 | 0.80 | BRAF (0.62) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL2191357 | 0.80 | BRAF (0.60) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL2193272 | 0.79 | BRAF (0.65) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL1727977 | 0.79 | BRAF (0.72) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL2193527 | 0.79 | BRAF (0.64) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL9989012 | 0.79 | BRAF (0.64) | BRAFLCKLYNTGFBR1BTK | |
| SCHEMBL2192679 | 0.78 | BRAF (0.83) | BRAFLCKLYNTGFBR1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |