Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1155718 | 0.78 | BRD4 (0.56) | BRD4KDM4EGSK3AGSK3BPKM | |
| SCHEMBL31698248 | 0.76 | BRD4 (0.37) | BRD4HRH3DYRK1AKDM4E | |
| SCHEMBL31698269 | 0.76 | HRH3 (0.45) | BRD4HRH3DYRK1A | |
| SCHEMBL13181194 | 0.74 | MAPK14 (0.49) | HRH3KDM4EADORA2AADORA2B | |
| SCHEMBL24820991 | 0.73 | BRD4 (0.48) | BRD4HRH3KDM4ERAB9A | |
| SCHEMBL3589633 | 0.72 | NQO1 (0.50) | MMP2MMP3MMP9MMP14KDM4E | |
| SCHEMBL21477298 | 0.69 | BRD4 (0.40) | BRD4DYRK1AMETGSK3AGSK3B | |
| SCHEMBL13181192 | 0.68 | GAA (0.56) | HRH3KDM4ERAB9A | |
| SCHEMBL197283 | 0.66 | FYN (0.45) | MMP2MMP3MMP9MMP14 | |
| SCHEMBL14514637 | 0.66 | CA1 (0.58) | KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |