Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.44 |
| ▸ | KDR | P35968 | 8/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 8/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | FRK | P42685 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625511 | 0.84 | RAF1 (0.61) | RAF1KDREPHX2BRAFMAPK14 | |
| SCHEMBL14440754 | 0.78 | RAF1 (0.55) | RAF1KDREPHX2BRAFMAPK14 | |
| SCHEMBL13625521 | 0.78 | RPS6KB1 (0.42) | RAF1MAPK14RPS6KB1MEN1KMT2A | |
| SCHEMBL13315104 | 0.77 | CYP3A4 (0.43) | RAF1EPHX2MAPK14RPS6KB1MEN1 | |
| SCHEMBL13603438 | 0.75 | DDR2 (0.48) | RAF1KDREPHX2BRAFMAPK14 | |
| SCHEMBL14440755 | 0.73 | RAF1 (0.57) | RAF1KDREPHX2BRAFMAPK14 | |
| SCHEMBL4376141 | 0.71 | RAF1 (0.61) | RAF1KDREPHX2BRAFMAPK14 | |
| SCHEMBL4379926 | 0.70 | RPS6KB1 (0.57) | RAF1KDREPHX2BRAFMAPK14 | |
| SCHEMBL26545831 | 0.70 | BRAF (0.66) | RAF1KDREPHX2BRAFMAPK14 | |
| SCHEMBL4371871 | 0.70 | RPS6KB1 (0.71) | RAF1KDREPHX2BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612200-B2 | Inhibitors of protein kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20090192307-A1 | INHIBITORS OF PROTEIN KINASES | LOCUS PHARMACEUTICALS, INC. | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192307-A1 | INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K1, MAP3K19 | RAF1 37/4885KDR 960/4885EPHX2 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.