Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2193377 | 0.88 | BRAF (0.77) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL13625184 | 0.86 | BRAF (0.54) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL2192723 | 0.83 | BRAF (1.00) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL12349996 | 0.83 | BRAF (0.80) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL12350547 | 0.83 | BRAF (0.80) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL2193474 | 0.82 | BRAF (0.79) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL12350424 | 0.79 | BRAF (0.73) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL18636551 | 0.79 | BRAF (0.69) | BRAFKCNH2LCKLYNTGFBR1 | |
| SCHEMBL12350556 | 0.79 | BRAF (0.73) | BRAFKCNH2LCKLYNTGFBR1 | |
| Trifluoroacetic Acid SCHEMBL2194657 | 0.78 | BRAF (0.72) | BRAFKCNH2LCKLYNTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |