Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1071459 | 1.00 | PDE4B (0.48) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1071461 | 1.00 | PDE4B (0.48) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1518501 | 1.00 | PDE4B (0.48) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1071462 | 1.00 | PDE4B (0.48) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1070516 | 0.87 | TACR1 (0.44) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1070514 | 0.87 | TACR1 (0.44) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1072540 | 0.87 | TACR1 (0.49) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1072548 | 0.87 | TACR1 (0.49) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL1072543 | 0.87 | TACR1 (0.49) | PDE4BTACR1KDM4EMAPTTHRB | |
| SCHEMBL953506 | 0.82 | TACR1 (0.61) | PDE4BTACR1KDM4EGPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |