Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 19/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL759932 | 0.88 | AURKA (0.76) | AURKAAURKB | |
| SCHEMBL759305 | 0.87 | AURKA (1.00) | AURKAAURKBEGFR | |
| SCHEMBL756748 | 0.85 | AURKA (0.83) | AURKAAURKB | |
| SCHEMBL763869 | 0.85 | AURKA (0.83) | AURKAAURKB | |
| SCHEMBL757769 | 0.85 | AURKA (1.00) | AURKAAURKB | |
| SCHEMBL757342 | 0.84 | AURKA (0.73) | AURKAAURKB | |
| SCHEMBL763140 | 0.83 | AURKA (0.60) | AURKAAURKB | |
| SCHEMBL759112 | 0.83 | AURKA (0.73) | AURKAAURKB | |
| SCHEMBL757597 | 0.83 | AURKA (0.79) | AURKAAURKBEGFR | |
| SCHEMBL759897 | 0.80 | AURKA (0.89) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276346-B1 | FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORA KINASE INHIBITORS | NAT HEALTH RESEARCH INSTITUTES (TW) | 2016-11-23 | — | — | EP | disclosed |
| WO-2009134658-A2 | FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORA KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-11-05 | — | — | WO | disclosed |