Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626140 | 0.90 | BTK (0.39) | BTKJAK2JAK1JAK3NTRK1 | |
| SCHEMBL13626376 | 0.88 | BTK (0.37) | BTKJAK2JAK1JAK3 | |
| SCHEMBL13626824 | 0.87 | BTK (0.48) | BTKJAK2JAK1JAK3 | |
| SCHEMBL13626827 | 0.87 | BTK (0.47) | BTK | |
| SCHEMBL13626468 | 0.87 | BTK (0.49) | BTK | |
| SCHEMBL13626831 | 0.84 | BTK (0.51) | BTK | |
| SCHEMBL13626133 | 0.83 | BTK (0.57) | BTK | |
| SCHEMBL1423529 | 0.81 | BTK (0.49) | BTK | |
| SCHEMBL13626126 | 0.81 | BTK (0.49) | BTKJAK2JAK1 | |
| SCHEMBL13626374 | 0.75 | BTK (0.41) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |