Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | SETD2 | Q9BYW2 | 4/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422735 | 0.81 | BTK (0.52) | JAK2BRD4BTK | |
| SCHEMBL1422805 | 0.73 | JAK2 (0.53) | JAK2 | |
| SCHEMBL1422466 | 0.73 | BTK (0.55) | BTK | |
| SCHEMBL1422423 | 0.70 | SYK (0.46) | JAK2BTK | |
| SCHEMBL1422569 | 0.70 | BTK (0.56) | BTK | |
| SCHEMBL1784125 | 0.67 | BTK (0.52) | BTK | |
| SCHEMBL1423347 | 0.67 | BTK (0.52) | BTK | |
| SCHEMBL1784132 | 0.67 | BTK (0.59) | BTK | |
| SCHEMBL1422629 | 0.66 | BTK (0.44) | BRD4BTK | |
| SCHEMBL1423339 | 0.66 | BTK (0.52) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |