Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593614 | 0.90 | F10 (0.59) | F10 | |
| SCHEMBL13626511 | 0.86 | F10 (0.70) | F10MAPT | |
| SCHEMBL76239 | 0.80 | F10 (0.72) | F10MAPTPTGS2 | |
| SCHEMBL76238 | 0.80 | F10 (0.72) | F10MAPTPTGS2 | |
| SCHEMBL14533691 | 0.79 | F10 (0.48) | F10 | |
| SCHEMBL4605212 | 0.79 | F10 (0.54) | F10 | |
| SCHEMBL77879 | 0.79 | F10 (0.75) | F10MAPTPTGS2 | |
| SCHEMBL4606642 | 0.79 | F10 (0.54) | F10 | |
| SCHEMBL77878 | 0.79 | F10 (0.75) | F10MAPTPTGS2 | |
| SCHEMBL76591 | 0.79 | F10 (0.73) | F10MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |