Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726018 | 0.93 | KDM4E (0.47) | KDM4EALDH1A1MCL1GAAPTGES | |
| SCHEMBL5725655 | 0.84 | PSEN1 (0.36) | KDM4EALDH1A1MCL1GAAMEN1 | |
| SCHEMBL13399037 | 0.81 | HPGD (0.41) | KDM4EALDH1A1MCL1MEN1KMT2A | |
| SCHEMBL5726098 | 0.80 | CA12 (0.37) | KDM4EALDH1A1LMNA | |
| SCHEMBL5724977 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1KMT2AHPGDL3MBTL1 | |
| SCHEMBL5724744 | 0.79 | PTGER4 (0.42) | KDM4EALDH1A1ALOX5PPARGPPARA | |
| SCHEMBL5726712 | 0.78 | KDM4E (0.49) | KDM4EPPARG | |
| SCHEMBL13398705 | 0.77 | HPGD (0.42) | KDM4EALDH1A1MCL1MAOBMEN1 | |
| SCHEMBL5724984 | 0.77 | CA12 (0.42) | KDM4EALDH1A1GAAKMT2AL3MBTL1 | |
| SCHEMBL5726241 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1MCL1PPARGKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622475-B2 | EP2 agonists | PFIZER INC (US) | 2009-11-24 | — | — | US | disclosed |