Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 17/20 | 0.66 |
| ▸ | KDR | P35968 | 17/20 | 0.66 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627506 | 0.96 | PDGFRA (0.65) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL12503726 | 0.92 | PDGFRA (0.67) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL1894171 | 0.92 | PDGFRA (0.67) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL14437187 | 0.91 | PDGFRA (0.66) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL1891137 | 0.91 | PDGFRA (0.66) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL1895108 | 0.91 | PDGFRA (0.66) | PDGFRAKDRMETAXL | |
| SCHEMBL1894204 | 0.90 | PDGFRA (0.65) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL1896758 | 0.90 | PDGFRA (0.78) | PDGFRAKDRMETAXL | |
| SCHEMBL1888465 | 0.90 | PDGFRA (0.64) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL1892702 | 0.90 | PDGFRA (0.64) | PDGFRAKDRMETAXLHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |